THE BIG IDEA
What if your doctor had a simple blood test that could predict Alzheimer’s Disease 15 years before any symptoms begin? Would you take it?
How about a test that could predict the likelihood of getting Parkinson’s Disease, multiple sclerosis, and dementia?
Let’s say Miracle...
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THE BIG IDEA
Nobody wakes up in the morning and says, “I’m fired up to buy stock in an Enterprise Work Management software company today.”
But not all investment ideas are sexy. Or make for a good story to tell friends. Or even sound a bit...
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THE BIG IDEA
On June 21, 2018 Supreme Court Justice Anthony Kennedy issued his final decision before retiring, and reshaped the laws that will govern future taxation on interstate e-commerce sales.
For decades, states had been prohibited from collecting sales taxes on residents’ transactions when were...
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THE BIG IDEA
Fortunately, most people don’t ever have to think too seriously about donating an organ, or receiving an organ transplant. Perhaps they ponder it for a few moments when getting a new driver’s license. But that’s often as far as the thought goes...
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THE BIG IDEA
Let’s talk proteins.
Proteins are the large, complex molecules that do the lion’s share of the work in your cells and are essential for all living organisms. They’re made up of hundreds of thousands of amino acids, smaller units that are attached long,...
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THE BIG IDEA
A lot of attention is given to the companies that develop blockbuster drugs. Far less attention is paid to those that make the sophisticated manufacturing equipment that allow drugs to be developed, made for clinical trials, then produced at scale when approved.
These...
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THE BIG IDEA
Read slowly. This will take some time to digest.
We are on the verge of a renaissance in the industrial manufacturing industry that will forever change how products are designed, built and introduced to market.
This renaissance is being driven by the same that...
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THE BIG IDEA
Warren Buffett is widely considered one of the best investors in history. Over the last 53 years Berkshire Hathaway’s (BRK/A) per-share market value has grown at an average annual rate of 21%. That works out to 10% better, every year, than S&P...
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THE BIG IDEA
The size of the market for electronic business-to-business (B2B) payments is hard to wrap your mind around. In the U.S. alone, it’s estimated that current B2B payment volume tops $20 trillion.
That’s a lot of Benjamins exchanging hands.
Even in such a big there’s...
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THE BIG IDEA
The year was 1956. Peter Pappas, originally from Cyprus, had recently returned to New York City after fighting in the Korean War. Sensing a need for food deliveries to local restaurants, Mr. Pappas teamed up with his cousin and founded the Butter...
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THE BIG IDEA
Warby Parker launched in 2010 selling eyeglasses online. With prices starting at just $95, its glasses have always been a lot less expensive than many alternatives out there, especially for buyers used to going through traditional eyeglass channels.
The business came about its...
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THE BIG IDEA
You’re as smooth as Tennessee whiskey,
You’re as sweet as strawberry wine,
You’re as warm as a glass of brandy,
And I stay stoned on your love all the time.
- Lyrics from Tennessee Whiskey, originally recorded by David Allen Coe, 1981
A few weeks ago, heard...
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THE BIG IDEA
If you’ve spent much time in the United Kingdom you might be familiar with Reading Buses. The company has been transporting passengers in and around Berkshire, England and the greater London area for over a century. Its fleet of 180 brightly single-...
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THE BIG IDEA
Are you concerned about cyberattacks?
Are your mobile devices, smart home devices and computers secure on your home network? What about in your car? At work?
These are questions people try not to think about too much. But the evidence suggests a dramatic in...
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THE BIG IDEA
Ever so slowly, biotech stocks are making a comeback.
The biotech index is up 7% year-to-date, and up 29% since the beginning of last year. Companies with good trial data and promising pipelines have garnered investors’ attention and their dollars.
The sector’s performance slightly...
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THE BIG IDEA
As the world moves toward knowledge-driven economies, continuous learning is critical. It’s not an option to just sit on your rear end if you want to get into a great college, land a terrific job, move up the corporate ladder or five...
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THE BIG IDEA
With most early-stage investments, who you buy is just as important as what you buy. In other words, a company’s leadership team is as important as its technology.
Which brings us to this man, Sunny Gupta.
Mr. Gupta grew up in India where dad...
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THE BIG IDEA
Remember when 3D printing stocks were all the rage?
Investors couldn’t buy them fast enough. And the technology was widely discussed as the having the potential to turn every garage in North America into a high-tech repair shop.
Then things just seemed to apart...
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THE BIG IDEA
I remember a consulting project I did for an academic medical center a number of years ago. The center was growing revenue at around 10% a year, had 12 divisions (Radiology, Surgery, Women’s Health, etc.), and was on the cusp of $650...
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THE BIG IDEA
A few months ago, my wife Jenni injured her back and was unable to get to the doctor’s office. Thankfully, we tracked down a highly recommended chiropractor, and he made a house call within 24 hours. After three days and three at...
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